Melanoma accounts for only 2 percent of all skin cancers in the United States. Still, it is the deadliest skin cancer. This is because this cancer can spread to other parts of the body. It can spread almost anywhere, including the lungs, bones, liver, brain, etc. Unfortunately, once it spreads to distal organs, it becomes incurable. Fortunately, with newer, better, immune- modulating drugs, we are seeing more patients doing better even in these difficult cases.